Siren, L.L.C.
Annual return '25
+16.3%
SPY '25
+17.7%
Alpha
-1.4ptsvs SPY
Invested
$3.6B
Holdings
100
Trades YTD
0
Performance · Fund vs SPY
Cumulative return · quarterly snapshotsCoverage 97%. 4 quarters of 2025 measured against SPY adj-close benchmark.
Top holdings · current snapshot
Source: 13F-HR01
$SRRK
Scholar Rock Holding Corp
Q4 2025: Exited (was 9.25M shares)
14.8%
02
$KYMR
Kymera Therapeutics Inc
Q4 2025: Exited (was 3.43M shares)
7.4%
03
$ERAS
Erasca Inc
Q4 2025: Exited (was 8.76M shares)
5.0%
04
$EWTX
Edgewise Therapeutics Inc
Q4 2025: Exited (was 3.90M shares)
3.9%
05
$ONC
BeOne Medicines AG
Q4 2025: Exited (was 493.0k shares)
3.8%
06
$TNGX
Tango Therapeutics Inc
Q4 2025: Exited (was 5.88M shares)
3.3%
07
$BCAX
Bicara Therapeutics Inc
Q4 2025: Exited (was 5.22M shares)
3.2%
08
$RVMD
Revolution Medicines Inc
Q4 2025: Exited (was 1.04M shares)
3.0%
09
$ARWR
Arrowhead Pharmaceuticals Inc
Q4 2025: Exited (was 2.67M shares)
2.8%
10
$MANE
Veradermics Inc
Held since at least Q1 2024
2.6%
Recent trades · Last 90 days
No Form 4 / 13D / 13G trade events on file in the recent window. 13F filers report position snapshots quarterly rather than per-trade events, so this section is most useful for managers who also file Form 4 or 13D/G.
Convergence · Pattern Engine ships in v1.1
30-day windowIn development
Convergence participation lands with the Pattern Engine.
Once the Pattern Engine ships, this section will list every active convergence event this fund is named in — with the other named funds, the Congress members on the same name, and combined position size.
Source data: SEC EDGAR · 13F-HR filings · Performance through 2025-12-31 · Last refreshed 10:33 UTC.