5AM Venture Management, LLC
Annual return '25
+8.9%
SPY '25
+17.7%
Alpha
-8.8ptsvs SPY
Invested
$360.2M
Holdings
20
Trades YTD
0
Performance · Fund vs SPY
Cumulative return · quarterly snapshotsCoverage 94%. 4 quarters of 2025 measured against SPY adj-close benchmark.
Top holdings · current snapshot
Source: 13F-HR01
$ERAS
ERASCA INC
Q4 2024: New position (5.41M shares)
15.7%
02
$TRDA
ENTRADA THERAPEUTICS INC
Q3 2025: Sold 1.2% (4.31M → 4.26M shares)
14.2%
03
$TYRA
TYRA BIOSCIENCES INC
Q4 2024: New position (939.3k shares)
10.9%
04
$CAMP
CAMP4 THERAPEUTICS CORP
Q3 2025: Increased +100.5% (2.93M → 5.87M shares)
7.2%
05
$CNTA
CENTESSA PHARMACEUTICALS PLC
Q3 2025: Sold 18.1% (830.9k → 680.9k shares)
6.4%
06
$PHVS
PHARVARIS N V
Q4 2024: New position (797.6k shares)
6.3%
07
$MPLT
MAPLIGHT THERAPEUTICS INC
Held since at least Q1 2024
5.4%
08
$TECX
TECTONIC THERAPEUTIC INC
Q1 2025: Sold 14.2% (596.7k → 511.7k shares)
5.2%
09
$CLDX
CELLDEX THERAPEUTICS INC NEW
Q4 2024: New position (497.3k shares)
4.4%
10
$ARTV
ARTIVA BIOTHERAPEUTICS INC
Q4 2024: New position (2.35M shares)
4.2%
Recent trades · Last 90 days
No Form 4 / 13D / 13G trade events on file in the recent window. 13F filers report position snapshots quarterly rather than per-trade events, so this section is most useful for managers who also file Form 4 or 13D/G.
Convergence · Pattern Engine ships in v1.1
30-day windowIn development
Convergence participation lands with the Pattern Engine.
Once the Pattern Engine ships, this section will list every active convergence event this fund is named in — with the other named funds, the Congress members on the same name, and combined position size.
Source data: SEC EDGAR · 13F-HR filings · Performance through 2025-12-31 · Last refreshed 12:14 UTC.