Opaleye Management Inc.
Annual return '25
+16.6%
SPY '25
+17.7%
Alpha
-1.1ptsvs SPY
Invested
$759.2M
Holdings
53
Trades YTD
0
Performance · Fund vs SPY
Cumulative return · quarterly snapshotsCoverage 100%. 4 quarters of 2025 measured against SPY adj-close benchmark.
Top holdings · current snapshot
Source: 13F-HR01
$HROW
HARROW INC
Q4 2025: Exited (was 3.91M shares)
13.2%
02
$LQDA
LIQUIDIA CORPORATION
Q4 2025: Exited (was 2.62M shares)
11.7%
03
$ETON
ETON PHARMACEUTICALS INC
Q4 2025: Exited (was 2.86M shares)
9.3%
04
$SLGL
SOL-GEL TECHNOLOGIES LTD
Q4 2025: Exited (was 204.8k shares)
5.2%
05
$RYTM
RHYTHM PHARMACEUTICALS INC
Q4 2025: Exited (was 461.7k shares)
4.7%
06
$APGE
APOGEE THERAPEUTICS INC
Q4 2025: Exited (was 363.3k shares)
4.3%
07
$IRON
DISC MEDICINE INC
Q4 2025: Exited (was 193.8k shares)
3.5%
08
$URGN
UROGEN PHARMA LTD
Q1 2025: Exited (was 220.0k shares)
3.4%
09
$CBIO
CRESCENT BIOPHARMA INC.
Held since at least Q1 2024
3.2%
10
$STOK
STOKE THERAPEUTICS INC
Q4 2025: Exited (was 682.0k shares)
3.0%
Recent trades · Last 90 days
No Form 4 / 13D / 13G trade events on file in the recent window. 13F filers report position snapshots quarterly rather than per-trade events, so this section is most useful for managers who also file Form 4 or 13D/G.
Convergence · Pattern Engine ships in v1.1
30-day windowIn development
Convergence participation lands with the Pattern Engine.
Once the Pattern Engine ships, this section will list every active convergence event this fund is named in — with the other named funds, the Congress members on the same name, and combined position size.
Source data: SEC EDGAR · 13F-HR filings · Performance through 2025-12-31 · Last refreshed 10:40 UTC.